program

CONFERENCE PROGRAM

MONDAY, SEPTEMBER 23

13:00 – 17:00LUPA pre-meeting
16:00 – 19:00Registration
18:00 – 21:00Welcome reception

TUESDAY, SEPTEMBER 24

8:20Official Welcome Kerstin Lindblad-Toh & Jerold Bell
Chair: Jerold Bell, Tufts Cummings School of Veterinary Medicine, N. Grafton, Massachusetts
8:40 – 9:30KEYNOTE SPEAKER
Gus Aguirre
, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania

SESSION 1 : Canine and Feline Evolution

Chair: Kerstin Lindblad-Toh, Broad Institute – Cambridge, Massachusetts & Uppsala University, Uppsala, Sweden

9:30

Analysis of recent and ancient canine genomes suggest a new hypothesis for dog origins
Robert Wayne, University of California – Los Angeles, Los Angeles, California

9:50

Haplotype structure reveals population history and selection in modern dogs
Adam Boyko, Cornell University, Ithaca, New York

10:10

The geographic diversification of domestic cats
Razib Khan, University of California – Davis, Davis, California

10:30 – 11:00

MORNING BREAK

SESSION 2 : Metabolic Traits

Chair: Danika Bannasch, University of California, Davis – Davis, California

11:00

Genome-wide association study of calcium oxalate urolithiasis in the miniature schnauzer
Eva Furrow, University of Minnesota, Minneapolis, Minnesota

11:20

Canine Imerslund-Gräsbeck syndrome (I-GS): Molecular heterogeneity of selective intestinal cobalamin malabsorption with proteinuria
John Fyfe, Michigan State University, East Lansing, Michigan

11:40

Unraveling the phenotypic and genetic complexity of canine cystinuria
Paula Henthorn, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania

12:00 – 13:00

LUNCH

SESSION 3 : Cancer I

Chair: David Sargan, University of Cambridge, Cambridge, United Kingdom

13:00

Histiocytic sarcoma in flat-coated retrievers
Jennie L. Rowell, National Human Genome Research Institute, Bethesda, Maryland

13:20

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
Elinor Karlsson, Broad Institute, Cambridge, Massachusetts

13:40

cMYC transactivated miR-17-92 cluster plays a crucial role in osteosarcoma progression by targeting tumor suppressor driver genes
Jyotika Varshney, University of Minnesota, Minneapolis, Minnesota

14:00 – 15:40       POSTER SESSION 1 with coffee. ODD NUMBERS

SESSION 4 : Neurological Disease I

Chair: Elinor Karlsson, Broad Institute, Cambridge, Massachusetts

15:40

The whole genome sequence of a Jack Russell terrier with progressive spinocerebellar ataxia and myokymia contains a homozygous disease-associated KCNJ10 missense mutation
Douglas Gilliam, University of Missouri – Columbia, Columbia, Missouri

16:00

You’re getting on my nerves! Feline orofacial pain syndrome
Barbara Gandolfi, University of Missouri, Columbia, Missouri

16:20

Association of an intronic repeat expansion with spinocerebellar ataxia in the Italian Spinone +Investigating the genetics of late onset spinocerebellar ataxia in the Parson Russell Terrier
Oliver Forman, Animal Health Trust Newmarket, United Kingdom

16:50

ADJOURN

DINNER ON YOUR OWN

WEDNESDAY, SEPTEMBER 25

8:20Morning announcements

SESSION 5 : Genomics I

Chair: Bob Wayne, University of California – Los Angeles, Los Angeles, California

8:30

Genetic signatures of selection in the domestic cat lineage
Wesley Warren, Washington University School fo Medicine, St. Louis, Missouri

8:50

Construction of a SNP-array based high-density genetic linkage map in domestic cat
Alex Makunin, Saint-Petersburg University, Saint-Petersburg, Russia

9:10

Phylogenomic analysis of the felid radiation using genome-wide SNPs, gene family supertrees and complete mitochondrial genomes
Gang Li, Texas A&M University, College Station, Texas

SESSION 6 : Canine Genome Workshop

9:30

Canine Genome Workshop: Genome Improvement, Annotation & Exome Capture
Broad group

10:20 – 10:50

MORNING BREAK

SESSION 7 : Behavior

Chair: Cathryn Mellersh, Animal Health Trust, Newmarket, United Kingdom

10:50

Simple behavioral pattern: Is it simple?
Anna Kukekova, University of Illinois at Urbana-Champaign, Champaign, Illinois

11:10

Genomic Approaches to Identify Putative Canine Behavior-Associated Genes
Tara Baxter, Cornell University, Ithaca, New York

11:30

Comparative approach to OCD genetics: case-control target sequencing in dog and human OCD
Hyun Ji Noh, Broad Institute, Cambridge, Massachusetts

11:50 – 13:10

LUNCH

SESSION 8 : Enzyme Disorders

Chair: Adam Boyko, Cornell University, Ithaca, New York

13:10

Imerslund-Gräsbeck syndrome (IGS) or selective cobalamin malabsorption is inherited as a monogenic autosomal recessive trait and has been described in humans and several dog breeds
Tosso Leeb, University of Bern, Bern, Switzerland

13:30

Molecular genetic heterogeneity of feline prophyria
Urs Giger, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania

13:50 – 15:20       POSTER SESSION 2 with coffee. EVEN NUMBERS

SESSION 9 : Morphology and Disease

Chair: Tosso Leeb, University of Bern, Bern, Switzerland

15:20

Dogs as animal models for orofacial clefts
Zena Wolf, University of California – Davis, Davis, California

15:40

Coordinate analysis of multiple dog body size loci
Maud Rimbault, National Human Genome Research Institute, Bethesda, Maryland

16:00

Genome-wide association study to identify QTLs for morphological traits in the domestic dog
Jessica Hayward, Cornell University, Ithaca, New York

16:20

Mapping genetic contributors to canine hind limb conformation
Dayna L. Dreger, National Human Genome Research Institute, Bethesda, Maryland

16:40

ADJOURN

17:30       BUSSES DEPART FOR EVENING ENTERTAINMENT

THURSDAY, SEPTEMBER 26

8:20Morning announcements
Chair: Wesley Warren, Washington University, St. Louis, Missouri
8:40 – 9:30KEYNOTE SPEAKER
Eric Lander
, Broad Institute, Cambridge, Massachusetts

SESSION 10 : Neurological Disease II

Chair: Ned Patterson, University of Minnesota, Minneapolis, Minnesota

9:20

Genome-wide association mapping in dogs identifies the homeobox gene, NKX2.8, in the etiology of neural tube defects in humans
Noa Safra, University of California – Davis, Davis, California

9:40

Canines within the biomedical continuum: deciphering pathomechanisms of centronuclear myopathies through comparative functional analyses integrating dog, mouse and cellular models
Laurent Tiret, École Nationale Vétérinaire d’Alfort, Maisons-Alfort, France

10:00 – 10:40

MORNING BREAK

SESSION 11 : Genomics II

Chair: Bill Murphy, Texas A&M University, College Station, Texas

10:40

A catalogue of common canine coding variants
Claire Wade, University of Sydney, Sydney, Australia

11:00

Automated classification of long non-coding RNAs in the domestic dog
Christophe Hitte, University of Rennes 1, Rennes, France

11:20

Supporting the cat genome assembly with physical and linkage genetic maps
Leslie Lyons, University of Missouri – Columbia, Columbia, Missouri

11:40 – 13:00

LUNCH

SESSION 12 : Cancer II

Chair: Catherine André, University of Rennes, Rennes, France

13:00

The Belgian Shepherd’s tale: genome-wide study across 9 dog breeds reveals an association of fructosamine concentration to a locus in Belgian Shepherd
Simon Forsberg, Swedish University of Agricultural Sciences, Uppsala, Sweden

13:20

Interaction between the immune system and malignant cells is indicated to play a common role in tumorigenesis for two malignancies in golden retrievers
Noriko Tonomura, Broad Institute, Cambridge, Massachusetts

13:40

Development of a genome-anchored microarray platform for identification of clinically predictive somatic DNA copy number aberrations in feline cancers
Rachael Thomas, North Carolina State University, Raleigh, North Carolina

SESSION 13 : Funding Agency Workshop

14:00

Funding Agency Workshop:
Terry Warren, Canine Health Foundation
Patricia Olson, American Humane Association

15:00 - 15:30

AFTERNOON BREAK

SESSION 14: Eye Disease

Chair: Anita Oberbauer, University of California – Davis, Davis, California

15:30

A novel frameshift mutation in Papillon and Phalène dogs with progressive retinal atrophy
Saija Ahonen, University of Helsinki, Helsinki, Finland

15:50

A SINE insertion that results in exon-skipping is associated with PRA in Tibetan spaniels and Tibetan terriers
Louise Downs, Animal Health Trust, Newmarket, United Kingdom

16:10

Identification of a mutation in CNGB1 causing progressive retinal atrophy in Papillon dogs + A mutation in SLC45A2 causes oculocutaneous albinism in white Doberman pinscher dogs
Paige Winkler, Michigan State University, East Lansing, Michigan

16:40

ADJOURN

DINNER ON YOUR OWN

FRIDAY, SEPTEMBER 27

8:50Morning announcements
Chair: Elaine Ostrander, National Human Genome Research Institute, Bethesda, Maryland
9:00 – 9:50KEYNOTE SPEAKER
Gill Bejerano
, Stanford University, Stanford, California

SESSION 15 : Cancer III

Chair: Elaine Ostrander, National Human Genome Research Institute, Bethesda, Maryland

9:50

Germ-line risk factors are associated with upregulation of genes mediating cell cycle arrest and stem cell activity in canine hemangiosarcoma
Jong-Hyuk Kim, University of Minnesota, Minneapolis, Minnesota

10:10

Genome-wide association of canine mast cell tumours in golden retrievers: two populations leading to a common pathway
Maja Arendt, Uppsala University, Uppsala, Sweden

10:30 – 11:00

COFFEE BREAK

SESSION 16 : Diseases Medley

Chair: John Fyfe, Michigan State University, East Lansing, Michigan

11:00

Genomic analysis identifies a complex genetic basis for feline hybrid sterility
Bill Murphy, Texas A&M University, College Station, Texas

11:20

Identifying disease-causing sequence variants in whole genome sequences from individual affected dogs
Gary Johnson, University of Missouri – Columbia, Columbia, Missouri

11:40

Genome-wide analysis in german shepherd dogs reveals association of a locus on CFA27 with atopic dermatitis
Katarina Tengvall, Uppsala University, Uppsala, Sweden

12:00

Closing remarks

12:15

ADJOURN (lunch boxes are available for conference attendees)



Nestle Purina
Broad Institute